报告时间：2025年3月17日下午15:30-17:00

报告人：Prof. Antonios G. Mikos (Rice University)

报告地点：清华大学逸夫技术科学楼C217会议室

邀请人：王秀梅老师

报告题目：Extracellular Matrix-Based Biomaterials for Tissue Engineering

报告简介：

Extracellular matrices hold great promise as tissue engineering scaffolds because of the wealth of contained biochemical cues that aid in tissue formation and regeneration. However, there are challenges with their use in tissue engineering applications due to insufficient physicochemical properties including mechanical and rheological properties and degradation characteristics. We have investigated the decellularization of different musculoskeletal tissues for the development of extracellular matrix-based biomaterials for diverse applications, and have examined the effects of material attributes, such as functionalization and crosslinking density, on cell behavior and tissue guidance. This presentation will review recent examples of extracellular matrix-based approaches from our laboratory for the regeneration of bone, cartilage, and skeletal muscle.

报告人简介：

Prof. Mikos is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice University. His research focuses on the synthesis, processing, and evaluation of new biomaterials for use as scaffolds for tissue engineering, as carriers for controlled drug delivery, as non-viral vectors for gene therapy, and as platforms for disease modeling. Mikos is a Member of the National Academy of Engineering, the National Academy of Medicine, the American Academy of Arts and Sciences, the National Academy of Inventors, the Chinese Academy of Engineering, the Academia Europaea, the Royal Academy of Pharmacy of Galicia, and the Academy of Athens.